Prostaglandins and the lung.

Prostaglandins and the lung.

Evidence exists implicating prostaglandins as mediators of asthma and of chronic inflammation in the lung. In addition to their spasmogenic effects, PGs are also potent in vitro regulators of mediator secretion by basophils, mast cells, or lymphocytes. These regulatory effects of E-series PGs may have considerable significance in drug design and evaluation in both asthma and chronic inflammation.

Biosynthesis of prostaglandins from arachidonic acid in guinea pig lung. Prostaglandins and related factors. 38.

The prostaglandins constitute a class of physiologically active compounds with a widespread occurrence in animal tissues (see References 2 and 3). Previous studies have led to the determination of their structures (4-S), and more recent investigations have shown that they can be formed enzymatically from the essential fatty acids (7,8). It was thus shown that in homogenates of vesicular glands ...

Prostaglandins evoke a whole variety of responses in the lung.

Rapid intravenous (IV) injections of the prostaglandin precursor arachidonic acid (AA) increase pulmonary arterial pressure (PAP) and pulmonary vascular resistance (PVR) in a variety of species. It has recently been reported that infusions of AA decrease PAP. The purpose of this report is to contrast responses to bolus injections and infusions of AA in the anesthetized dog. In all experiments r...

Prostaglandins and the kidney.

Prostaglandins and the kidney.

This review provides a summary and assessment of research involving renal prostaglandins. Arachidonic acid released from phospholipids is converted by prostaglandin cyclo-oxygenase in the kidney to PGF2, PGF2alpha, PGD2, and, possibly, to PGI2 and thromboxane A2. Production of PGE2 and PGF2alpha is predominately but not exclusively in the medulla, whereas degradative enzymes are present in both...